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Wednesday, December 6, 2023

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A cross section of a newley transplanted cardiac stem cell. A cross section of a newley transplanted cardiac stem cell.

Rejuvenating Aged Hearts

SDSU Heart Institute researchers successfully rejuvenated damaged and aged heart tissue with modified stem cells.

San Diego State University’s Heart Institute has made a breakthrough discovery that could one day lead to new treatments for heart-failure patients.

SDSU researchers successfully rejuvenated damaged and aged heart tissue of older heart-failure patients with scientifically modified stem cells.

“Since patients with heart failure are normally elderly, their cardiac stem cells aren’t very healthy,” said Sadia Mohsin, one of the study's authors and a post-doctoral research scholar at SDSU’s Heart Institute.

“We modified these biopsied stem cells and made them healthier. It is like turning back the clock so these cells can thrive again.”

Modifying Stem cells

Modified human stem cells helps the signaling and structure of the heart cells, which were biopsied from elderly patients. Researchers modified the stem cells in the laboratory with PIM-1, a protein that promotes cell survival and growth.
Cells were rejuvenated when the modified stem cells enhanced activity of an enzyme called telomerase, which elongates the length of telomeres length. Telomeres are “caps” on the ends of chromosomes that facilitate cell replication. Aging and disease results when telomeres break off.

“There is no doubt that stem cells can be used to counter the aging process of cardiac cells caused by telomere degradation,” Mohsin said.

The technique increased telomere length and activity, as well as increasing cardiac stem cell proliferation, all vital steps in combating heart failure.

Clinical treatment advancements 

While human cells were used, the research was limited to the laboratory. Researchers have tested the technique in mice and pigs and found that telomere lengthening leads to new heart tissue growth in just four weeks.

Mohsin says modifying aged human cardiac cells from elderly patients adds to the cell’s ability to regenerate damaged heart muscle and makes stem cell engineering a viable option.

“This is an especially exciting finding for heart failure patients,” Mohsin said. “Right now we can only offer medication, heart transplantation or stem cell therapies with modest regenerative potential, but PIM-1 modification offers a significant advance for clinical treatment.”
This study was presented at the American Heart Association’s Basic Cardiovascular Sciences 2012 Scientific Sessions and simultaneously published in the Journal of the American College of Cardiology.

This study was supported by the National Institutes of Health.